Changes in hepatic CINC levels (A) and MPO activity (B) in rats subjected to hepatic I/R. Animals were subjected to 60 minutes of hepatic ischemia followed by reperfusion as described in Materials and Methods. Sham-operated animals were prepared in a similar manner, except that blood flow to the left and median hepatic lobes was not obstructed. Mean values of the hepatic CINC level and MPO activity after various periods of hepatic reperfusion are shown. Data represent the mean ± SD derived from six animal experiments. (□) Sham-operated animals; (▪) I/R animals. §P < .01 versus preischemia. *P < .01 versus sham.