The recognition of the HCL cells by the BV2⁺ and the BV8S3⁺ T-cell clones was restricted by HLA-DQA1*03/DQB1*0301 and HLA-DPB1*04, respectively. Panel studies were performed to further determine the restriction of recognition of the HCL cells by the T-cell clones. Proliferation of the BV2⁺ T-cell clones 4F10 and 1F2 (A) and the BV8S3⁺ T-cell clone (B) in response to HCL cells from different patients are shown.