Thrombin generation in PRP of a patient with mild type IIa vWF deficiency. The patient’s plasma contained 30% factor VIII and ≈ 4% of vWF antigen. (□) Control PRP (with 10 μg/mL rabbit IgG); X, patient’s PRP (rabbit IgG added); (•) patient’s PRP preincubated with anti-vWF antibody (10 μg/mL). Inset: thrombin generation in PPP. (□) Normal control; (X) patient.