Thrombin generation in plasma of patient with type III severe vWD. The patient has less than 1% of factor VIII and vWF antigen and ristocetin cofactor activity. (Upper frame) (□) Normal PRP; (X) patient’s PRP; (⧫) patient’s PRP with 100% recombinant factor VIII added. (Lower frame) Thrombin generation in intrinsically triggered nondefibrinated PPP. (□) Normal PPP; (X) patient’s PPP; (⧫) patient’s PPP with 100% recombinant FVIII added.