Time course of initiating successive treatment regimens used in Total Therapy, consisting of VAD × 2 to 3 (see text), HDCTX + GM-CSF with subsequent PBSC collection, EDAP + GM-CSF; followed by two cycles of high-dose therapy with hematopoietic stem cell support (Tx-1 and Tx-2); followed by IFN maintenance after completion of two autotransplants (151 patients). Note that >95% of patients completed remission induction by 6 months, first transplant by 8 months, and second transplant by 15 months (for further details, see text). The time interval between first and second transplant regimen ranged from 2.4 to 11.2 months with a median of 4.5 months; 80% completed both transplants within 1 year of study enrollment.