Analysis of CR rate in relationship to time of onset of first PR among the 165 patients completing tandem transplants including 14 who received an allograft. The horizontal axis depicts the serial components of Total Therapy along with the number of patients achieving first PR status as a result of the indicated therapeutic intervention along with the cumulative PR rate. For example, 61 patients already responding to VAD (37%) had the highest CR rate after two transplants (64%) compared with a CR rate of 37% among the 22 patients attaining PR only after the first cycle of MEL 200 mg/m². Thus, CR rate was highest in VAD-sensitive myeloma.