Fig. 2.
Fig. 2. (A) NAC and lipoic acid (LA) blocked As2O3-induced apoptosis but not PML/RAR- degradation in NB4 cells. NB4 cells were treated with 2 μmol/L As2O3 alone or together with 10 mmol/L NAC or 100 μmol/L LA for 24 and 72 hours. Apoptotic cells were determined by fluorescence staining as described in Materials and Methods. Values are the mean of three independent experiments. (B) NAC and LA blocked As2O3-induced activation of Cpp32 and cleavage of PARP, but not PML/RAR- degradation in NB4 cells. Lane 1, control; lane 2, As2O3; lane 3, LA; lane 4, As2O3 + LA; lane 5, NAC; lane 6, As2O3 + NAC. Cells were treated with concentrations described above for 24 hours.

(A) NAC and lipoic acid (LA) blocked As2O3-induced apoptosis but not PML/RAR- degradation in NB4 cells. NB4 cells were treated with 2 μmol/L As2O3 alone or together with 10 mmol/L NAC or 100 μmol/L LA for 24 and 72 hours. Apoptotic cells were determined by fluorescence staining as described in Materials and Methods. Values are the mean of three independent experiments. (B) NAC and LA blocked As2O3-induced activation of Cpp32 and cleavage of PARP, but not PML/RAR- degradation in NB4 cells. Lane 1, control; lane 2, As2O3; lane 3, LA; lane 4, As2O3 + LA; lane 5, NAC; lane 6, As2O3 + NAC. Cells were treated with concentrations described above for 24 hours.

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