Lytic activity from splenocytes of DBA/2J mice after transfer of MIP-1−/− B6 splenocytes. DBA/2J mice were irradiated as indicated in the text and the following day received 1 × 10⁷ splenocytes from MIP-1−/− B6 or C57BL/6 mice. Fourteen days later, mice were killed, and their splenocytes were isolated and stimulated for 48 hours with irradiated (2,500 cGy) C57BL/6 or DBA/2J splenocytes. Lymphocytes were tested for lytic activity on con A blasts from C57BL/6 and DBA/2J mice as indicated in the text. Spontaneous release for each target cell was less than 20% of maximal. This is one of two experiments.