Sequences of the human FOP gene. A full-lengthFOP cDNA clone is shown with the predicted amino acid sequence of an open reading frame. Leucine residues that may correspond to a novel type of leucine-rich motifs are in bold. Putative -helices are underlined. Arrowheads indicate exon/intron boundaries. The arrow corresponds to the t(6;8) breakpoint. The asterisk indicates the stop codon.