The effect of anionic polysaccharides on the hemodynamic behavior of SS RBC in the ex vivo mesocecum vasculature. ▵▵PRU represents percent changes after untreated (none) SS control values were normalized to 100%. ▵▵PRU for AA RBC is ∼50% lower than for control SS cells. CSA (n=5), heparin (n=4), HDS (n=6), and LDS (n=3) resulted in significant decreases in PRU, ie, 28% (*P < .01), ∼27.7% (^#P < .05), ∼40% (P < .001) and ∼23% (⁺P < .05), respectively (paired t-test). CSB (n = 3) and HS (n = 4) did not have any significant effect on PRU.