FISH analysis of the U266 MM cell line. (A) Partial U266 metaphase hybridized with the chromosome 11 painting probe. (B) Partial U266 metaphase hybridized with the chromosome 14 painting probe. DAPI counterstaining is shown for each chromosome. (C) Partial U266 metaphase cohybridized with cosmid I4 (green), YAC 877-D-8 (green), and C1 (red) probes. For details concerning these probes, see text and Fig 1.