Effect of antisense p21 mRNA expression on nuclear morphology. (A) Wright-Giemsa stain of a mononuclear LXSN cells (upper left). The others are examples of multilobular cells and/or cells with two, three, or more apparent nuclei from AS21 cultures. (B) Quantitation of different nuclear morphologies in transduced cells. Data from three separate cultures were pooled. Two hundred cells per culture were scored. Mean ± SD of each morphology is compared.