Cells with multiple or deformed nuclei have multiple copies of some chromosomes. Fluorescence in situ hybridization of log phase cells using probe to centromere no. 7. Blue shows DAPI-stained DNA and red shows centromere no. 7 signal indicating the number of copies of chromosome no. 7. The upper three pictures show examples of LXSN cells that are mononuclear and are diploid, as indicated by two copies each of chromosome 7. The AS21 picture (bottom) shows an example of a single giant cell (center) with 4 nuclear lobular structures. Two of these lobes contain several copies of chromosome 7; therefore, this cell is polyploid.