Graph showing the effect of ibandronate treatment (4 μg per mouse per day) on serum IgG2b concentrations in 5TGM1 myeloma-bearing and control mice. Serum IgG2b levels were measured by ELISA. Data are mean ± SEM (n = 6). ∗, Significantly different from control + PBS. No significant differences were observed between myeloma-bearing animals treated with PBS or with ibandronate.