Comparison of the amino acid sequences of Gab1 and Gab2. The sequences of human and mouse Gab2 cDNA were deposited in the DNA Data Bank of Japan (DDBJ). Their accession numbers are AB018413 andAB018414, respectively. The PH domain, MBD, and tyrosine-based motifs for Grb2, Crk, p85 PI-3 kinase, and SHP-2 are underlined.