Fig. 5.
NO inhibits HIV-1 replication in MDM. HIV-1ADA was incubated with or without SNAP for 3 hours and then MDM was precultured for 7 days in DMEM medium were infected with non–SNAP-treated and SNAP-treated viruses. MDM infected with nontreated virus were maintained in the presence and absence of SNAP. Cultures were fed with fresh DMEM medium and SNAP was replenished every 3 days. Data are representative of three experiments and reflect the average levels of RT activity present in duplicate samples of supernatants, which differed by not more than 15%.
