Markers of endothelial cell activation in HPC donors receiving rHuG-CSF. Plasma levels of vWF (A) and TM (B) were determined before (T0), during (T1 and T2), and 1 week after stopping (T3) rHuG-CSF administration. Mean values and SD are shown. Dashed lines represent the cut-off of normal control values. Statistical analysis as in Fig 1. *P < .05, **P < .01 v T0.