Regulatory sequences used to control cDNA expression in various published murine APML models. cDNA sequences are represented as open boxes. Cathepsin G coding exons, included downstream of the PML/RARA or PLZF/RARA cDNAs, are represented by filled boxes. The 5′ untranslated regions of the respective targeting loci are represented by hatched boxes. The remainder of the targeting loci (upstream regulatory regions, intronic sequences, and 3′ untranslated regions) are represented by plain lines. The MRP8 targeting construct includes 3′ untranslated sequences placed downstream of the inserted cDNA. The CD11b targeting construct consists of upstream CD11b regulatory sequence and an SV40 polyadenylation signal (shaded box) located downstream of the cDNA. These representations are not drawn precisely to scale.