GVL effect after allo-BMT. GVL effect was evaluated in BDF1 mice that were inoculated IV with 1 × 10⁴ L1210 cells (A) or 1 × 10⁵ P815 cells (B) 2 days before the BMT as described in Fig 1A. (A) Mice inoculated with L1210 and P815 cells died within 8 and 10 days, respectively, when they received irradiation alone without BMT (no BMT). Transfer of B6 TCD-BM or syngeneic BDF1 BMS resulted in early leukemia relapse. Recipients of B6 BM or BMS survived longer than the above-noted three groups, but all mice died within 60 days. Data represent the results of three similar experiments.