The effect of dose on the pharmacokinetics of pGCR in mice. pGCR, at doses of 50 (▪), 40 (⧫), 20 (* ), or 10 (▴) U/kg, was injected into the tail vein of mice. Tail vein bleeds were collected at 0.25-minute intervals and analyzed for glucocerebrosidase activity. Best fit exponential curves are plotted.