Uptake and stability of rGCR in (A) KC and (B) PC after IV administration in Balb/c mice. Mice were injected IV with pGCR (▴) or rGCR (⧫) at doses of 40 U/kg. At designated times postinjection, two animals from each group were killed, collagenase perfused, and hepatocellular populations separated as described in Materials and Methods. Values presented are the average and range of the duplicate determinations. Solid lines are theoretical plots.