Time-dependent effect of fenofibrate on fibrinogen A-chain mRNA levels. Adult male rats were treated with 0.5% (wt/wt) fenofibrate for different time periods. Total RNA was extracted from livers and analyzed for fibrinogen A-chain mRNA levels by dot-blot analysis as described in Materials and Methods. Equal loading was checked by hybridizing with an 18S rRNA cDNA probe. Values are means ± SD of three animals and presented as percentage of control values. Statistically significant differences (P < .05) are indicated by an asterisk.