Effect of cessation of fenofibrate treatment on fibrinogen A-chain mRNA levels. Adult male rats were treated with 0.5% (wt/wt) of fenofibrate for 14 days, after which fenofibrate was withdrawn from the food. Total RNA was extracted from livers and analyzed for fibrinogen A-chain mRNA at different time points after cessation of fenofibrate treatment. Equal loading was checked by hybridizing with an 18S rRNA cDNA probe. Values are means ± SD of three animals per group and presented as percentage of control values obtained from untreated animals (C). Statistically significant differences (P < .05) are indicated by an asterisk.