Effect of ciprofibrate and fenofibric acid on fibrinogen production in primary cultures of rat hepatocytes. Isolated rat hepatocytes were incubated with 0.3 or 1 mmol/L ciprofibrate or fenofibric acid or vehicle for three consecutive periods of 24 hours. The conditioned media were analyzed for fibrinogen antigen as described in Materials and Methods. Results are means ± SD of three independent experiments performed in duplicate. The data are expressed as percentage values of controls. Statistically significant differences (P < .05) are indicated by an asterisk.