Effect of fibrates on fibrinogen and ACO gene transcription. Nuclear run-on assays were performed on nuclei obtained from livers of control rats and rats treated with 0.5% (wt/wt) fenofibrate or 0.5% (wt/wt) ciprofibrate for 14 days as described in Materials and Methods. The data shown are of a representative experiment. (A) Autoradiogram showing vector (pSG5), β-actin, ACO, and fibrinogen A-chain (Fbg A) signals. (B) Signals were quantified by densitometric scanning and adjusted for the corresponding β-actin signal. Data are expressed as percentage values relative to that in control nuclei.