Effect of BRL 49653 and fenofibrate on fibrinogen A-chain mRNA levels in rats. Adult male rats were treated with 10 mg/kg of body weight/day BRL 49653 or 400 mg/kg of body weight/day fenofibrate by gavage twice a day for 3 days. Plasma triglyceride levels were determined as described in Materials and Methods. Total RNA was extracted from livers and analyzed for fibrinogen A-chain mRNA by Northern blotting. Equal loading was checked by hybridizing with an 18S rRNA cDNA probe. Values are means ± SD of two independent experiments (with four animals per group) and presented as percentage of control values. Statistically significant differences (P < .05) are indicated by an asterisk.