Effect of fenofibrate on fibrinogen A-chain mRNA levels in wild-type versus PPAR-null mice. Wild-type (+/+) and PPAR-null (−/−) mice were treated with 0.2% (wt/wt) fenofibrate mixed in chow for 17 days. Total RNA was extracted from livers and analyzed for fibrinogen A-chain by Northern blotting. Equal loading was checked by hybridizing with an 18S rRNA cDNA probe. Values are means ± SD of seven animals per group and presented as percentage values of control, untreated wild-type mice.