Fig. 8.
Effect of the anti-CD11b MoAb VIM12 on the GM-CSF–stimulated neutrophil-mediated Lym-1 antibody-dependent cytolysis. 51Cr-labeled Raji cells were at 2 × 104. The neutrophil-Raji cell ratio was 20:1. Lym-1 and GM-CSF were at 10 μg/mL and 1 ng/mL, respectively. The incubation time was 14 hours. The lysis was 26.71 ± 21.62 (mean ± 1 SD, n = 8) with a median of 19.15 (confidence interval 95%, 8.64 to 44.79) in the absence of VIM12 and 49.3 ± 22.01 (mean ± 1 SD, n = 8) with a median of 54.50 (confidence interval 95%, 30.89 to 67.70) in the presence of VIM12. Cytolysis in the absence versus that in the presence of VIM12 was P = .037.