Effect of the NMDA channel blocker, MK-801, on CD41 (GPIIb/IIIa) expression by MEG-01 cells. Charts show flow cytometric analyses of CD41 expression by (A) untreated MEG-01 cells, (B) MEG-01 cells treated with PMA (10⁻⁷ mol/L), and (C) MEG-01 cells treated with PMA (10⁻⁷ mol/L) and MK-801 (10⁻⁴ mol/L) for 3 days. Representative contour plots are shown indicating forward-scatter (FS, cell size) against CD41-FITC fluorescence (FL1). Events lying within the F gate indicate CD41 positivity. PMA-stimulated increases in cell size and CD41 expression (compare A and B) are reduced in the presence of MK-801 (C). See Table1.