Effect of NMDA receptor antagonists on MEG-01 adhesion. MEG-01 cells were cultured in the absence (▪) or presence (□) of PMA (10⁻⁷ mol/L). (A) The noncompetitive antagonist, MK-801, and (B) the competitive antagonist, D-AP5, caused significant dose-dependent inhibition of PMA-stimulated adhesion. MTT assays of parallel cultures indicated that MK-801 (C), and D-AP5 (D), had no effect on cell numbers or viability. Values are means ± SEM (n = 4). *P < .05, **P < .01, ***P < .005v controls (t-test).