Pathological analysis of acute leukemia developed inE2A-HLF transgenic mice. (A) Macroscopic appearance of a leukemic mouse. The enlarged thymus and spleen are indicated by black and white triangles, respectively, and subcutaneous lymph node swellings are indicated by arrows. (B) WG-stained peripheral blood smear of a leukemic mouse. Massive proliferation of lymphoblasts is apparent. (C through F) HE-stained thymus (C), spleen (D), liver (E), and kidney (F) of a leukemic mouse. The fundamental structures of the thymus and the spleen are destructed due to massive proliferation of leukemic cells (C and D, respectively) and infiltration of leukemic cells is detected around the blood vessels in the liver and the kidney (E and F, respectively).