Fig. 1.
Fig. 1. Clonal origin of EBV-infected NK cell leukemia. (A) NK leukemia cells in peripheral blood bear a morphology of large granular lymphocytes (a) (May-Grünwald-Giemsa staining; original magnification × 1,000); NK leukemia cells in peripheral blood (case no. 1) (b) and in the liver (case no. 1) (c) expressed EBER1 RNA on in situ hybridization, indicating that virtually all NK cells were infected with EBV. (B) Southern blot analysis of DNA extracted from NK-enriched PBMCs showed that each sample possessed a single joined terminal sequences of the EBV genome (EcoRI digestion), indicating their clonal origin from a single EBV-infected NK cell. The numbers on the top of each lane correspond to case numbers listed in Table 1. “C” is a positive control DNA from EBV-infected lymphoepithelioma that contains a single episomal from of EBV.

Clonal origin of EBV-infected NK cell leukemia. (A) NK leukemia cells in peripheral blood bear a morphology of large granular lymphocytes (a) (May-Grünwald-Giemsa staining; original magnification × 1,000); NK leukemia cells in peripheral blood (case no. 1) (b) and in the liver (case no. 1) (c) expressed EBER1 RNA on in situ hybridization, indicating that virtually all NK cells were infected with EBV. (B) Southern blot analysis of DNA extracted from NK-enriched PBMCs showed that each sample possessed a single joined terminal sequences of the EBV genome (EcoRI digestion), indicating their clonal origin from a single EBV-infected NK cell. The numbers on the top of each lane correspond to case numbers listed in Table 1. “C” is a positive control DNA from EBV-infected lymphoepithelioma that contains a single episomal from of EBV.

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