Macroscopic appearance of a CAM (day 12) implanted simultaneously at day 8 with a sponge loaded with the plasma cell CM of an active (progression) MM patient alone (*) and with a second sponge loaded with the same CM added with an anti–FGF-2 antibody (**). Note the angiogenesis toward the one-asterisk sponge (some neovessels are arrowheaded), and its inhibition by the anti–FGF-2 antibody. Bar, 2 mm.