DNA-binding proteins that interact with the −450 to +12 bp gp91^phox promoter. The transcriptional repressor CDP competes with the binding of transcriptional activators at multiple elements.10-12 The DNA-binding activity of CDP is downregulated during terminal phagocyte development, thereby permitting the interaction of transcriptional activators such as BID, CP1, IRF-1, and IRF-2 with the promoter. +1 indicates the position of transcription initiation. Two IFN-stimulated response elements (ISRE) are denoted by open boxes. The −63 to −33 bp promoter region is indicated below the diagram.12 The core consensus binding sequence (GGAA) of the ets family of transcription factors is underlined, and the positions of point-mutations identified in CGD patients17 18 are indicated by arrows.