DFS and overall survival by cytogenetic risk groups and treatment periods (earlier protocols: 8011, 8411, and 8513; later protocols: 8811, 9111, and 9311). (A through D) DFS; (E through H) overall survival. (A and E) all patients; (B and F) unfavorable risk group; (C and G) miscellaneous cytogenetic abnormalities group; (D and H) normal cytogenetics group.