Proposed pathway generated from CD34 and CD43. Crosslinking of either CD34 or CD43 leads to tyrosine phosphorylation and cell polarization (capping/uropod formation) for cytoadhesion and perhaps cell motility. NaF affects tyrosine phosphorylation of Lyn, pp60, pp69, Syk, and pp77 from the initial phase of stimulation, resulting in inhibition of cell polarization and cytoadhesion. Cyt.D suppresses not only tyrosine phosphorylation of Syk and pp77, but also cytoadhesion by inhibiting cell polarization through disruption of the actin cytoskeleton. Both CD34 and CD43 trigger activation of a common cascade of tyrosine phosphorylation signaling.