Fig. 1.
Structures of full-length and mutant G-CSFR introduced into WEHI-3B D+ and LGM-1 cells by electroporation. The mutant G-CSFRs are designated by the letters of the alphabet (A, B, C, D, E, and F) and their degrees of truncation from the C-terminus of the cytoplasmic domain are illustrated. The cytokine receptor superfamily homology regions (Box 1, Box 2, and Box 3) are represented by boxes, and the four tyrosine residues (Tyr703, Tyr728, Tyr743, and Tyr763) in the murine G-CSFR cytoplasmic domain are indicated by “Y.” Amino acids are denoted by aa.