Hematopoietic and neural tissue-specific transcription in the 6.0ISLacZ transgenic mouse. Whole-mount LacZ staining of 9.5 (A and B) and 11.5 (E and F) dpc embryos with 6.0ISLacZ transgene (line 869) is shown. Panel B shows a transgene-negative littermate (9.5 dpc), and C and D is a sagittal section of A. Panel D is a higher magnification of C. Original magnifications are ×25 (C), and ×200 (D). Panel F is a dorsal view of the embryo in panel E, showing that LacZ reporter-positive cells reside in the anterior horn of the spinal cord. Upper limb buds were eliminated to show the staining in the trunks. Abbreviations: a, dorsal aorta; s, somites; n, neural tube.