Fig. 5.
Treatment of the BCL1 lymphoma with RIT late in the disease. Groups of 10 mice were given 106 cells on day 0 as usual and then left until day 14 before treating IV with radioiodinated MoAb (750 μg/animal [approximately 7.5 MBq]). The treatments included: Control IgG (⋆); control IgG2a (⧫); anti-Id (□, ▪); anti-MHC II (TI2-3; ○, •); and anti-MHCII (N22; ▿, ▾). The solid and open symbols represent MoAb labeled with and without radioactive iodine, respectively. Surprisingly the131I–anti-Id MoAb provided long-term protection to all the mice.