Fig. 4.
Pattern of hematological reconstitution in the lethally irradiated, transplanted baboons. Complete blood counts were performed on the animals before irradiation to establish baseline values at 24- to 72-hour intervals after completion of myeloablation, and biweekly after engraftment and removal from the tether system when applicable. Differential counts of 100 nucleated peripheral blood cells, where possible, were performed to determine the ANC. The initial 60-day course of the seven animals’ ANCs are depicted in the upper panel and platelet counts in the lower panel. PA6216 () received no graft; PA6126 (- - - - - ) and PA6594 (•••••) received a suboptimal number of mononuclear marrow cells; PA6592 (— — — ) received a sufficient mononuclear marrow cell graft; PA6245 (--------- ) was infused with a sufficient number of selected, unexpanded CD34+ marrow cells; PA6156 (-•-•-•-•- ) and PA6188 (—•—•— ) were given grafts composed of the cellular product of CD34+ marrow cells expanded for 10 days in PMVEC coculture.