(A) Breakpoint at chromosomes 1 and 11. The 5′ exons of NUP98 were previously described.22 The location of the primers used for RT-PCR is indicated. (B) Detection of fusion transcripts between NUP98 and PMX1 exon 2 and between NUP98 and PMX1 exon 1b. A 270-bp product ofNUP98-PMX1 exon 2 fusion and a 168-bp product ofNUP98-PMX1 exon 1b fusion were observed, whereas noPMX1 exon 1a-NUP98 fusion was seen. MWM, 123-bp ladder molecular weight marker. + and − indicate the presence and absence of RT reaction, respectively. (C) Nucleotide and deduced amino acid sequences of NUP98-PMX1 fusions.