FISH analysis of MM patients. (A) and (B) Interphase nuclei of patients 24 and 9, respectively, hybridized with the JH (green), YAC 764-H1 (red), and the -satellite chromosome 4 (green) probes. The colocalized JH/YAC signals are indicated by an arrow, and the signals specific for centromeric chromosome 4 sequences by an arrow head. (C) Metaphase from case no. 30 hybridized with the JH (green) and YAC 764-H1 (red) probes. Colocalized signals at the putative der(4) chromosome are indicated by an arrow, and der(14) by X. (D) Metaphase from case no. 18 hybridized with the JH (green) and YAC 764-H1 (red) probes. The colocalized signals on the telomeric region of chromosome 4p are indicated by an arrow.