Hypothermia is independent of thrombocytopenia induction. Dose-dependency of hypothermia (A), thrombocytopenia (B), and platelet-bound MWReg30 levels upon IV injection of the indicated amount of MWReg30 in 200 μL PBS. The hypothermia is expressed as the decrease in degrees Celcius measured 60 minutes after injection, whereas platelet counts and platelet antirat Ig staining were performed 3 hours after injection. Results are expressed as the means from 3 mice per group ± SD.