Serum IgM (A) and IgG3 (B) concentrations in reconstituted and control mice measured at 6-week intervals postreconstitution. Time (in weeks) postreconstitution is on the x-axis and Ig concentration in micrograms per milliliter is on the y-axis. The stippled area represents the range seen in 9 CBA/J normal control mice and the (⧫) denotes the CBA/N xid control levels (5 mice). For the reconstituted mice that were all lethally irradiated (900 rad, 5 mice per group), (○) and (▵) denote mice that received 5.0 × 106 total cells, of which 5% or 0.5% were normal, respectively; (□) corresponds to mice that received 0.5 × 106 total cells, of which 5% were normal; (◊) indicates the 3 responding mice that received 0.5 × 106 total cells, of which 0.5% were normal, and (*) shows the 2 mice in this group that did not have significantly increased serum IgG3.
