CD19 exerts its growth-inhibitory on KMS-5 in vivo. A total of 5 × 10⁶ cells of each clone was inoculated subcutaneously in SCID-hIL-6 transgenic mice. After 5 weeks mice, were killed and tumors resected and measured as described in Materials and Methods. The statistical data are drawn from 5 animals injected with each clone, and the P value is shown above the horizontal bars. The mean ± SD values for each group were as follows: neo-control (5,007 ± 1,212); K-19⁺ #8 (2,756 ± 1,877); K-19⁺⁺ #3 (854 ± 375); and K-19⁺⁺ #11 (269 ± 336). Each point represents 1 animal.