Transcript levels of chromosome 21-localized genes in myeloblasts from newly diagnosed AML patients. Median CBS and SOD transcript levels were 12.0- and 3.8-fold higher, respectively, in DS myeloblasts compared with non-DS myeloblasts (A and B). Transcript levels of the dCk gene were 2.6-fold higher in DS compared with non-DS cells (C). Transcript levels were normalized to 18S RNA transcript levels. Horizontal bars represent the median values in each group.