Mutant CHEB mice and 269 mice kidneys. (A) MouseCHEBm30 no. 1, kidney, electron microscopy (original magnification × 6,000). (B) Mouse CHEBm94 no. 1, kidney, electron microscopy (original magnification × 2,500). (C) Mouse 269 no. 10, kidney, electron microscopy (original magnification × 4,000): moderate or heavy increase of lysosomal component in proximal tubular cells with variable apical vacuolation secondary to reabsorption of mutated CHEB or 269 LCs. Crystalline inclusions are absent in the lysosomal compartment.