American Society of Hematology

Fig. 2.

$Fig. 2. Electron micrographs of 104-g fraction, and fractions from the sucrose gradient. (a) Plasma membrane-derived microvesicles; (b) exosomes; (c and d) microvesicles and exosomes. (c) Immunolabeling for CD63; note the difference in size between the CD63 positive exosomes and the microvesicle; (d) immuno-double labeling for GPIb and CD63; exosomes are enriched in CD63, while microvesicles (upper left in d) contain predominantly GPIb. Bars: (a) 500 nm; (b through d) 100 nm.$

Electron micrographs of 10⁴-g fraction, and fractions from the sucrose gradient. (a) Plasma membrane-derived microvesicles; (b) exosomes; (c and d) microvesicles and exosomes. (c) Immunolabeling for CD63; note the difference in size between the CD63 positive exosomes and the microvesicle; (d) immuno-double labeling for GPIb and CD63; exosomes are enriched in CD63, while microvesicles (upper left in d) contain predominantly GPIb. Bars: (a) 500 nm; (b through d) 100 nm.

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