Representative histological appearance of 6-19–induced glomerular lesions. The sections of the ear from untreated normal mice (A) and 6-19–treated FcRγ+/− (B), FcRγ−/− (C), and TNFβ−/− (D) mice were prepared 12 days after the IP injection of 6-19 hybridoma cells. Tissues sections were stained with HE (original magnification × 400). 6-19–treated FcRγ+/− mice developed glomerulonephritis with global proliferative and exudative changes (B). FcRγ−/− and TNF−/− mice developed similar glomerular lesions (C and D).