Fig. 7.
![Fig. 7. PP1 dose-dependently inhibits alboaggregin-A–induced platelet aggregation and 5-HT secretion. Platelets were preincubated for 3 minutes at 37°C with 0.25% DMSO or various concentrations of PP1 (indicated on the right of the graphs) before stimulation with alboaggregin-A (3.5 μg/mL) for 1 minute. Platelet aggregation was measured as a decrease in optical density of a stirred platelet suspension and 5-HT release was measured after loading cells with [3H]-5-HT. Both platelet aggregation and release of 5-HT are presented as percentages of the responses induced in the absence of PP1. Data presented are means ± SEM for 3 experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/94/5/10.1182_blood.v94.5.1648/5/blod41731007x.jpeg?Expires=1735523754&Signature=WBXVoCv5oRHG2HkDqdFLG37jKTcaGvne0Q--tmYNtXtfn66b0zz7MPQENMlZ3-nCadpZM0rq2zj4wZs3H7Nnpr0M8dnQHUTDBxhL2u0ruRUf9JZdWZoUWhUAxtKV6IJd25GF~r8jQYWaoJ16i2j1VU6R26c27wN37KcYuOC2L1H5MyiDf-FEOhw~~~niVoy8q3LU4unkBmA~xTe7jDYTkYAyk~9AYWbmYAhNRtEZrx5ls4SDq7kQ5x2dOqauGlKH9Xdhc4XaoR2udaofwOT8HG0Hr-Y3DdbL5XHqaOVaUHbq~0GByJGtb84GssY0EkADVMUV89nnDZji0gAZ7EH2uQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PP1 dose-dependently inhibits alboaggregin-A–induced platelet aggregation and 5-HT secretion. Platelets were preincubated for 3 minutes at 37°C with 0.25% DMSO or various concentrations of PP1 (indicated on the right of the graphs) before stimulation with alboaggregin-A (3.5 μg/mL) for 1 minute. Platelet aggregation was measured as a decrease in optical density of a stirred platelet suspension and 5-HT release was measured after loading cells with [3H]-5-HT. Both platelet aggregation and release of 5-HT are presented as percentages of the responses induced in the absence of PP1. Data presented are means ± SEM for 3 experiments.
